Extended - spectrum XDR Tuberculosis in Beijing with Discordant Whole - 1
نویسندگان
چکیده
26 Drug-resistance to tuberculosis remains a major public health threat. Here, we report two cases 27 of extended-spectrum XDR (XXDR) tuberculosis, resistant to most first and second-line agents. 28 Correlation of whole-genome sequencing (WGS) and phenotypic testing was discordant, 29 suggesting over-reliance on WGS may miss clinically relevant resistance in extensively drug30 resistant disease. 31
منابع مشابه
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Drug resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum extensively drug-resistant (XXDR) tuberculosis showing resistance to most first- and second-line agents. The results of a correlation of whole-genome sequencing (WGS) and phenotypic testing were discordant, suggesting that overreliance on WGS may miss clinically relevant resistan...
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